The coast of the Río Negro province presents hunter-gatherer-fisher occupations dated from the Middle to the Late Holocene, a period in which the utilization of marine and terrestrial resources is recorded, as well as the manufacturing of a wide variety of lithic artifacts using mainly four types of rocks. In previous papers, we studied the use of lithic raw materials at a regional level, comparing different areas of the San Matías Gulf. In this paper, the scale of analysis focuses on six specific archaeological localities, which are dated through the entire human occupation of the area. The aim is to analyze changes over time within each set of lithic materials, and to determine if the scales continue to show the regional trends established in previous papers. Technological and raw material analyses were performed, and statistical methods were applied to establish general trends in the samples. The results indicate that, unlike previous studies, the type of rocks that were used varied over time, and that several of the studied localities also show significant variations in the other indicators that were analyzed (cortex percentage, broken vs. unbroken artifacts, among others).